PBC is a progressive autoimmune liver disease characterized by the destruction of intrahepatic bile ducts that, if left untreated, can lead to liver failure and, ultimately, the need for liver transplantation. This multimedia eHealth Source™ has been designed to support early identification of disease, as well as the timely implementation of effective therapy for PBC. Specific topic areas covered in this activity include guideline-directed diagnostic and prognostic measures, monitoring and treatment modification procedures, data for the use of newly US Food and Drug Administration–approved peroxisome proliferator–activated receptor (PPAR) agonists, and strategies for translating evolving evidence to practice. Clinical evidence will be augmented with video commentary from expert faculty and patients with PBC, providing invaluable insight on lived experiences and actionable recommendations for practicing clinicians.