High-performance computing has innumerable traits and issues to explore and to find related solutions. This book facilitates the reader by offering detailed ideas about the several essential aspects of high performance computing related matters such as Multi-Step-Ahead forecasting, Latent Semantics Indexing, Grid computing, Real-Time Scheduling in Cloud Computing, Incentive-based Scheduling Algorithms to Provide a Green Computing infrastructure, Security mechanism for large and complex data transportation in a parallel computing platform, and Data compression mechanism of large and complex data. Furthermore, it offers detailed literature studies to explore the ongoing issues and existing corresponding solutions to resolve these issues. This book has presented literature studies to further analyze the persisting research gap by examining the strengths and shortcomings of such exiting solutions. Decisively, the corresponding solution to address the prevailing issues have also been served in this book. The proposed solutions for each outstanding issue are also examined as per their performance and effectiveness using distinct benchmarking parameters.